DEG CAS 111-46-6, also known as diethylene glycol, is a clear, colorless, hygroscopic liquid widely used as a solvent, humectant, and chemical intermediate in industrial and pharmaceutical settings. Its versatile properties make it applicable in everything from polyester resins and brake fluids to cosmetics and pharmaceutical formulations, but its potential deg toxicity means that safe handling and strict compliance are paramount. Diethylene glycol SDS documents are essential for risk management.

DEG CAS 111-46-6 Toxicity & Health Risks

The toxicity profile of DEG CAS 111-46-6 is well documented: this compound is moderately toxic if ingested, inhaled, or absorbed through the skin. Animal studies have shown that oral LD50 values in rats range around 13–21 g/kg, which indicates significant risk at sufficient doses.

In humans, ingestion of diethylene glycol has been linked to severe renal and liver damage as well as central nervous system (CNS) depression in documented poisoning incidents. Its metabolism produces harmful intermediates such as DGA, which contribute to deg toxicity and have been implicated in proximal tubule cell damage in the kidneys.

Key Safety Data from DEG SDS

According to safety documentation (SDS):

• Signal word: Warning

• Hazard statements: H302 (Harmful if swallowed)

• Precautions: Avoid breathing vapors/mist; use chemical goggles and gloves; seek medical advice if exposed.

• Fire hazard: Combustible with a high flash point (~138 °C).
  These details are standard for diethylene glycol SDS and help inform protective measures.

Flammability of DEG CAS 111-46-6

One common question about deg is its flammability. Although diethylene glycol is combustible under certain conditions, its flash point is high (~138 °C), which categorizes it as less flammable than many industrial solvents. Its low vapor pressure also reduces airborne ignition risk at room temperature. However, permeable protective measures remain crucial when storing or handling the material, especially near oxidizing agents or high heat sources.

Shelf Life & Storage Considerations

The deg shelf life is generally around 24 months when stored properly—sealed and away from heat and direct sunlight. High-purity grades often recommend use within 12 months after opening to maintain quality and prevent contamination. Temperature-controlled, dry, and ventilated storage helps mitigate risks of degradation or moisture uptake, which can impact performance in downstream applications.

Regulatory Landscape: deg reach status & Compliance

Regulatory frameworks such as REACH (Registration, Evaluation, Authorization, and Restriction of Chemicals) govern the use and distribution of chemical substances like deg cas 111-46-6 in the European Union. DEG is registered under REACH with full safety and hazard data, meaning manufacturers and distributors must provide compliant documentation including SDS and Risk Management Measures. This helps control occupational exposure and mitigates environmental impact. Vendors must supply SDS sheets and adhere to hazard labeling and transport regulations as mandated by REACH and global hazard communication standards. (interchimie)

Handling & Personal Protective Equipment (PPE)

Proper handling of deg cas 111-46-6 involves:

• Using chemical-resistant gloves and eye protection.

• Avoiding inhalation of vapors or aerosols, especially in enclosed spaces.

• Ensuring work areas are well ventilated.

• Keeping emergency showers and eye-wash stations accessible.
  These controls are aligned with SDS guidance to minimize deg toxicity risks during handling or accidental exposure.

Emergency Response & First Aid

In the event of exposure:

• Skin contact: Remove contaminated clothing; wash with soap/water.

• Eye contact: Rinse immediately for at least 15 minutes with clean water.

• Ingestion or inhalation: Seek immediate medical attention.
  Recognizing the signs of DEG poisoning quickly (nausea, kidney discomfort, CNS symptoms) is critical due to its metabolic effects on organs. Healthcare professionals use the diethylene glycol SDS as a basis for treatment protocols.

Environmental & Disposal Considerations

DEG is readily biodegradable and exhibits low potential for bioaccumulation due to its low log Kow (partition coefficient), but spill management is essential to prevent soil and water contamination. In case of accidental releases, the SDS recommends containment and proper disposal through licensed chemical waste management services. This reduces environmental impact and assures compliance with hazardous waste regulations.

Vonage Pharma Chemicals Category & Related Bulk Products

In addition to its flagship DEG CAS 111-46-6 offering, Vonage Pharma’s Chemicals portfolio includes other high-quality bulk products for providers:

• MEG (Monoethylene Glycol) – high-purity industrial and pharmaceutical grade.

• ETHYL ACETATE 99% – premium solvent with wide industrial applications.

• METHYL ACETATE 99% – high-purity solvent with consistent performance.

This range supports chemical providers’ needs across formulation, synthesis, and manufacturing use cases, ensuring both quality and safety documentation like SDS and COA.

Why Choose Vonage Pharma for DEG CAS 111-46-6

Vonage Pharma stands out as a leading bulk provider of DEG CAS 111-46-6 thanks to:

• Consistent high purity and quality backed by rigorous analytical testing.

• Comprehensive safety documentation, including timely diethylene glycol SDS compliant with global standards.

• Full regulatory support for compliant handling, storage, and transport.

Whether you require industrial solvents, intermediates, or a secure supply chain partner for hazardous chemicals, Vonage Pharma’s commitment to safety and performance ensures reliability.

Conclusion: Safe, Compliant Use of DEG CAS 111-46-6

A thorough DEG CAS 111-46-6 safety profile and regulatory guide underscores the need for careful handling, toxicity awareness, and compliance with standards like REACH and SDS requirements. With appropriate PPE, controlled storage, and quality documentation, chemical providers can leverage the versatility of diethylene glycol while mitigating risk. Partnering with a trusted bulk supplier ensures access to high-purity chemical products and robust safety support — a critical advantage in today’s complex chemical landscape.