Buprenorphine Base API – High Purity, GMP Certified
Buprenorphine is a partial opioid agonist and is used to control severe pain that does not respond to other treatments and requires opioid drugs. It is also used in the maintenance phase of opioid addiction treatment.
CAS No: 52485-79-7 | Molecular Formula: C29H41NO4 | Molecular Weight: 467.64 g/mol
Overview: Buprenorphine Base is a potent medication designed for effective pain management and the treatment of opioid use disorder. As a semisynthetic opioid, it provides significant analgesic effects while minimizing the risks associated with traditional full agonist opioids.
Key Features & Benefits of Buprenorphine Base
✅ GMP Certified – Produced under rigorous quality controls
✅ COA & DMF Available – Comprehensive regulatory documentation
✅ 99 %+ Purity – Premium pharmaceutical-grade material
✅ Bulk Supply Ready – Worldwide shipping with prompt delivery
✅ Storage: [below 30°C] | Shipping: [below 30°C]
Regulatory & Compliance
Pharmacopoeia Standards: USP/EP/BP/JP
DMF & COA Available upon request
Technical Specifications
| Parameter | Details |
| CAS No. | 52485-79-7 |
| Molecular Formula | C29H41NO4 |
| Molecular Weight | 467.64 g/mol |
| Indications | Opioid receptor partial agonist; analgesic |
| Storage Temp. | Store at controlled room temperature (below 30°C) |
| Shipping Temp. | Ambient or as required |
| Appearance | White to Off-White Crystalline Powder |
| Chemical Name | Buprenorphine Base |
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Buprenorphine is available in several formulations, including:
- Buprenorphine API: This formulation is used in various delivery methods, including tablets and implants.
- Buprenorphine Base
- Buprenorphine Hydrochloride
- Buprenorphine Sublingual: Buprenorphine Tablets allow for rapid onset of action as the medication dissolves under the tongue:
- Intermediates:
- N-Methylnorbuprenorphine 3-methyl ether
- (5R,6R,7S,9R,13S,14S,20S)-17-Cyclopropylmethyl-α-(1,1-dimethylethyl)-4,5-epoxy-18,19-dihydro-3,6-dimethoxy-α-methyl-6,14-ethanomorphinan-7-methanol
Indications of Buprenorphine Base
- Management of severe acute and chronic pain where other treatments are inadequate.
- Treatment of opioid use disorder as part of a comprehensive recovery program that includes counseling and behavioral therapy.
Dosage and Administration
It can be administered via various routes, including sublingual tablets and transdermal patches. The sublingual tablets should be placed under the tongue until fully dissolved.
Contraindications
- Hypersensitivity to buprenorphine or any components of the formulation.
- Significant respiratory depression or acute asthma in an unmonitored setting.
Warnings and Precautions
- Cardiovascular disease
- Hepatic impairment
- History of seizures or respiratory issues
Side Effects
Common side effects may include:
- Nausea
- Constipation
- Dizziness
- Headache
Manufacturer: Vonage Pharma (Former Pluvia Endo) manufactures Buprenorphine Base, ensuring high-quality standards and compliance with regulatory requirements.
For more information from Vonage Pharma (Former Pluvia Endo) or to place an order, don’t hesitate to contact us today!
FAQs
What is Buprenorphine Base API used for?
Buprenorphine Base API is a critical pharmaceutical ingredient used in medications to manage moderate to severe pain and treat opioid addiction. It offers a safer alternative with a lower risk of overdose.
Do you provide COA and regulatory documents?
Yes, we provide a Certificate of Analysis (COA), Material Safety Data Sheet (MSDS), and Drug Master File (DMF) support upon request.
What is the minimum order quantity (MOQ)?
The minimum order quantity (MOQ) varies based on region and customer requirements. Please contact us for detailed information.
How is the product shipped and stored?
Buprenorphine Base API is shipped under controlled conditions to ensure stability and should be stored at temperatures below 30°C.
Do you supply globally?
Yes, we supply pharmaceutical manufacturers worldwide, complying with regional regulatory standards.
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