Nalbuphine Hydrochloride

Product Overview

Nalbuphine Hydrochloride is a powerful opioid analgesic with a unique mixed agonist-antagonist profile, designed to provide effective pain relief while minimizing the risk of certain opioid-related side effects. It acts as an agonist at kappa opioid receptors and a partial antagonist at mu opioid receptors, delivering analgesic potency comparable to morphine on a milligram basis up to approximately 30 mg.

Vonage Pharma manufactures Nalbuphine Hydrochloride under rigorous GMP standards, ensuring high quality, safety, and consistent efficacy for healthcare providers managing moderate to severe pain.

Mechanism of Action

Nalbuphine Hydrochloride works by activating kappa opioid receptors, which modulate pain perception, while simultaneously blocking mu opioid receptors to reduce respiratory depression and lower the risk of dependence commonly associated with traditional opioids. This dual action allows nalbuphine to provide effective analgesia with a ceiling effect on respiratory depression, making it safer at higher doses compared to pure mu-opioid agonists.

The onset of analgesic effect occurs rapidly—within 2 to 3 minutes intravenously and within 15 minutes after subcutaneous or intramuscular injection. Its analgesic effects typically last between 3 to 6 hours.

Indications and Uses

• Management of moderate to severe pain, including perioperative pain

• Adjunct to balanced anesthesia

• Relief of pain where opioid analgesics are indicated but with potentially reduced adverse effect risks

• Suitable for patients requiring potent analgesia yet at risk of opioid-induced respiratory depression

Dosage and Administration

• Nalbuphine Hydrochloride is administered by intravenous, intramuscular, or subcutaneous injection

• Typical dosages range from 10 to 30 mg, depending on the severity of pain and patient response

• Doses above 30 mg do not increase respiratory depression due to the ceiling effect

• Use with caution in patients with opioid dependence; nalbuphine may precipitate withdrawal

Safety Profile and Side Effects

Nalbuphine Hydrochloride exhibits a favorable safety profile with fewer risks of euphoria and respiratory depression compared to pure mu-opioid agonists. Common side effects include:

• Sedation

• Dizziness

• Nausea and vomiting

• Sweating

• Clamminess

Rare but serious adverse reactions reported include respiratory depression (with other CNS depressants), hypersensitivity reactions, and precipitated opioid withdrawal in dependent patients.

Precautions and Contraindications

• Use caution in patients with a history of opioid dependence or abuse

• Not recommended in patients with known hypersensitivity to nalbuphine or related opioids

• Avoid use with other CNS depressants unless closely monitored

• Pregnancy and lactation use only when clearly needed under medical supervision

Packaging and Storage

• Available as injectable solution in concentrations of 10 mg/mL or according to specific formulations

• Store in a cool, dry place protected from light

• Keep out of reach of children

Why Choose Vonage Pharma’s Nalbuphine Hydrochloride?

Vonage Pharma guarantees top-quality Nalbuphine Hydrochloride manufactured under strict GMP protocols. Our product provides healthcare professionals with a reliable and effective analgesic option for managing moderate to severe pain, balancing analgesia with safety.